NFL DFS Picks for Week 5 DraftKings Main Slate

Alvin Kamara is back for Week 5 and ready to dominate. Here are the top picks at each position for DraftKings Week 5 NFL DFS main slate.

Sometimes, adjustments need to be made. The Lions were without a handful of their skill players in Week 4, leading me to swap out Dallas Goedert for T.J. Hockenson in my cash-game lineups on DraftKings. Hockenson proceeded to score 42.90 points, giving me my fourth straight week of profit in cash games to begin the 2022 campaign.

Jamaal Williams also contributed 26.90 points as one of the highest-rostered players in cash contests while Josh Allen recorded a solid 24.52 points at the QB position. Even though my cash-game lineup totaled 170.32 points in Week 4, Richie James Jr. and Khalil Herbert only combined for only 12 points as popular plays in cash contests.

In hopes to extend the streak to five weeks of profit, here are my favorite cash-game plays on DraftKings in Week 5.


Josh Allen vs. PIT ($8,200) 

It was an ugly weather game between the Ravens and the Bills in Week 1, and even with Allen throwing for only 213 yards, he still managed to post 24.52 points. The gunslinging quarterback for the Bills gives us such a high floor with 7.1 non-passing fantasy points per game, which is the fourth-most among quarterbacks.

I wouldn’t be against going with Jalen Hurts for only $100 cheaper on DraftKings if you’re spending up at quarterback, but I’d give the edge to Allen with a premier matchup against a weak secondary of the Steelers in Week 5.

Tom Brady vs. ATL ($6,000)

Jared Goff has a higher salary than Brady this week and with how they’ve both performed to begin the season, it’s actually justified. That being said, Brady is going to be popular this week versus the Falcons, and for good reason as Tampa Bay is slowly getting its offensive weapons back.

The future Hall of Famer is coming off his best game of the season with 29.4 points against the Chiefs and he now gets to face the Falcons at home. Brady is dealing with shoulder and finger injuries following Week 4, but unless he’s surprisingly ruled out, he’s a fantastic spend-down option at quarterback.

Trevor Lawrence vs. HOU ($5,600)

If you need to save even more salary at quarterback, Lawrence is in a perfect bounce-back spot after a dismal outing against the Eagles in Week 4. Lawrence fumbled the ball four times and threw an interception in a rainy game last week, however, he’ll be headed home to host the Texans in Week 5.

Before last week’s dud, the second-year quarterback for the Jaguars had notched 18+ DraftKings points in back-to-back weeks. Most sites have Lawrence as one of the best points-per-dollar plays at the quarterback position this week.

Running Backs

Leonard Fournette vs. ATL ($6,900)

The Buccaneers are going to be extremely popular this week in a home game where they’re heavily favored over the Falcons. Fournette has a massive workload at the running back position, and even when he ran for negative three yards in Week 4, he still put up 18.4 points.

Super Bowl Lenny has garnered 79.9% of Tampa Bay’s attempts and targets at the running back position, giving us an extremely high floor for cash games in a game where the Buccaneers are 8.5 point favorites and a team total of 28.25 (second-highest on the main slate).

Alvin Kamara vs. NO ($6,600)

Kamara was a surprise scratch in Week 4 with a rib injury against the Vikings in a game that took place in London. While the dynamic running back is questionable to suit up in Week 5, Kamara himself said that he’s playing this week.

Regardless of who the quarterback is for the Saints, Kamara has a favorable matchup against the Seahawks at home. Seattle’s defense allowed 5.3 yards per attempt (third-most in the NFL) and 24 receptions (tied for the sixth-most in the NFL) to running backs.

James Robinson vs. HOU ($6,300)

You have to possess a short memory in NFL DFS as each week can be different. With the Jaguars playing from behind in Week 4, Robinson registered a season-low 2.9 points as he saw a season-low eight attempts.

Before last week’s forgettable performance, the former undrafted running back had 51 of the 77 running back carries for the Jaguars with four total touchdowns. The positive news for Robinson is that the Texans are giving up the most fantasy points per game and the second-most rushing touchdowns (5) to running backs.

Wide Receivers

Cooper Kupp vs. DAL ($9,600)

There’s a good chance that if you insert Kupp into your lineup, you’re almost guaranteed to get 25+ points. You’ll have to spend a ton of your salary, but if you’re saving salary at other positions, he should be affordable this week against the Cowboys.

The reigning Offensive Player of the Year has a league-high 36% target share through the first four weeks and Matthew Stafford seems to hate Allen Robinson. I’m fine going down to Stefon Diggs if you’re unable to afford Kupp on DraftKings.

Mike Evans vs. ATL ($6,900)

Once again, the Buccaneers are going to be popular in cash games and GPPs in Week 5 against the Falcons. Following a one-game suspension, Evans returned in Week 4 and proceeded to score 33.3 points with 2 touchdowns vs the Chiefs.

I have a feeling that Tampa Bay makes a concerted effort to throw the ball more in Week 5 to get the passing game back on track after a slow start to the season. Evans continues to be overlooked in fantasy football, but he’s going to be targeted often by Brady and his touchdown upside always makes him a threat to put up double-digit points.

Zay Jones vs. HOU ($4,100)

The Jaguars are also in a position to be a semi-popular team in Week 5 in a home matchup with the Texans. Jones missed Jacksonville’s Week 4 loss to the Eagles, however, the veteran wideout is trending toward returning to the field on Sunday.

Before missing last week’s game, Jones had two games of nine-plus targets, and he recorded 24.5 points in Week 3. With the former second-round pick being a favorite target for Lawrence, his salary is much cheaper than it should be on the green site.

Tight Ends

Tyler Higbee vs. DAL ($4,300)

The Rams are lacking receiving options in the offense right now, and with Van Jefferson sidelined, Higbee is operating as Stafford’s No. 2 pass-catching weapon. Here’s the list of tight ends that have a higher target share than Higbee at the tight end position: Mark Andrews. That’s the entire list.

Even in a tough matchup against the Cowboys, Higbee has gotten nine-plus targets in three out of the first four weeks of the season. If the Lions don’t have Amon-Ra St. Brown and DJ Chark again in Week 5, Hockenson is viable in cash games if you have the extra $600 from Higbee.

David Njoku vs. LAC ($3,800)

We have finally gotten more Njoku in the offense of the Browns in recent weeks and the athletic tight end has made the most of his opportunities. The former first-round pick has five-plus targets in three out of the first four weeks and he’s combined for 34.6 points in the last two weeks.

While Njoku has a tough matchup against Derwin James in Week 5, he’s one of the top two receiving options for the Browns in a game where they could be playing from behind.

Hunter Henry vs. DET ($2,900)

DraftKings has certainly tightened up their salaries at the tight end position, but there’s a cheap tight end that could see a much bigger role in Week 5. Even though the Patriots could have their third-string quarterback in Bailey Zappe starting on Sunday, Henry could be the clear No. 1 tight end with Jonnu Smith doubtful to play and New England faces Detroit at home.

The Lions have surrendered the eighth-most fantasy points per game and they are tied for the third-most receiving touchdowns allowed to tight ends this season.


New York Jets vs. MIA ($2,600)

The Dolphins have already ruled out Tua Tagovailoa in Week 5, which means Teddy Bridgewater will be the starting quarterback on Sunday. The defense of the Jets hasn’t been great to start the season, but they did have four interceptions and three sacks in Week 4 en route to a season-high 12 points.

Dallas Cowboys @ LAR ($2,500)

As a Rams fan, it pains me to recommend the defense of the Cowboys on road this week. The offensive line is hampered by injuries for Los Angeles as Stafford has been sacked 16 times (tied for second-most in the NFL) while he’s also thrown a league-high six interceptions.

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