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NFL DFS Picks for Week 10 DraftKings Main Slate

JuJu Smith-Schuster will keep his hot streak going vs the Jaguars. The top plays at each position for DraftKings Week 10 NFL DFS main slate.

It was a stellar week for my DFS cash-game lineup in Week 9 as it produced my highest score of the season in cash games. By using Justin Fields at quarterback, I was able to fit in Tyreek Hill, Travis Etienne Jr., Rhamondre Stevenson, Tyler Lockett, and Joe Mixon.

Even with Tyler Higbee and the Carolina Panthers defense combining for negative 2 points, my cash-game lineup accrued 217.02 points on DraftKings. The lineup was good enough to cash in tournaments and it’s always good when you can hit every double-up and head-to-head contest you enter.

While I crack a big smile looking at my cash-game lineup from last week, let’s look at who I’m liking for cash games on DraftKings for the main slate in Week 10.


Patrick Mahomes vs. JAC ($7,900)

This Mahomes guy is pretty good at this football thing, huh? The superstar quarterback for the Chiefs just recorded a season-high 38.1 points in Week 9 despite only throwing 1 touchdown. Mahomes boasts a 0.53 PER (tied for second-highest among QBs) and he only got a $200 increase on DraftKings from a week ago. If you’re able to pay up at the quarterback position, there likely isn’t a safer pick than Mahomes at home against the Jaguars.

Justin Fields vs. DET ($6,500)

Gone are the days when we’ll be able to use Fields at a salary under $6,000 on DraftKings. The second-year quarterback now leads all QBs with 9.1 non-passing points per game after exploding for 45.7 points in Week 9 with a record-setting 178 rushing yards versus the Dolphins. Fields now has 12-plus rushing attempts in three out of the last four games for the Bears while also posting 60-plus rushing yards in four straight. Even with the increased salary, Fields gives us a safe floor with his rushing production and he faces a Lions defense that surrenders the third-most points per game to QBs.

Daniel Jones vs. HOU ($5,700)

Speaking of quarterbacks with rushing floors, Jones is essentially a poor man’s version of Fields. The Giants lack receiving weapons, so they’ve elected to let Jones run more this season to let him showcase his athletic ability. While the former first-round pick out of Duke has thrown for 200-plus yards just twice this season, he has six-plus carries in each of the first eight games and 10-plus carries in two out of the last four. I’m also fine going down to Trevor Lawrence at $5,400 if you absolutely need to.

Running Backs

Saquon Barkley vs. HOU ($8,600)

With the Giants coming out of the bye week, Barkley still leads all RBs with a massive 85% opportunity share. The second-highest is Josh Jacobs at 81.9%. Once again, New York doesn’t have many receiving weapons, so Barkley is consistently involved in the passing game. The stud running back also gets to square off against the Texans this week, who are allowing the most points per game to RBs thus far.

Travis Etienne Jr. @ KC ($7,100)

Etienne is now an RB1 moving forward with James Robinson no longer on the Jaguars. The second-year back has combined for 57.8 points on DraftKings in his first two starts and he’s now registered 22-plus points in three consecutive games. The Clemson product has received 24-plus attempts in back-t0-back weeks and I expect his targets to be around four-to-five instead of the two or three he’s seen the last two games. With the Jaguars likely involved in a shootout with the Chiefs, Etienne is certainly in play for cash games.

Dameon Pierce @ NYG ($6,300)

Pierce has been one of the bright spots on the Texans in his rookie season despite not being the starter to begin the year. Even in a game where Houston was defeated 29-17 versus the Eagles in Week 9, Pierce still managed to rush for 139 yards on 27 attempts. The first-year back has gotten 18-plus touches in six straight games and he should remain a focal point of the offense in Week 10 against the Giants. New York’s defense gives up the fourth-most yards per attempt to RBs this season, so Pierce has an opportunity to break a couple of runs on Sunday.

Wide Receivers

Tyreek Hill vs. CLE ($9,100)

There isn’t a wide receiver in the NFL that’s playing better than Hill right now. With Tua Tagovailoa back under center for the Dolphins, Hill has scored 30-plus points on DraftKings in three out of the last four games. Despite scoring only three touchdowns thus far, Hill is still averaging 24.7 points per game on the green site. More touchdowns should be on the horizon for the star wideout with a 31.1% target share and an impending matchup with the Browns. If you’re not able to fit Hill in your lineups, Jaylen Waddle is viable in cash games as well.

JuJu Smith-Schuster vs. JAC ($6,000)

I’m not saying that I don’t like Chris Olave at $6,800 for cash games, but I’m wondering how much longer we’ll be able to get Smith-Schuster at $6,000 or lower on DraftKings. Especially if he continues to have an expanded role in Kansas City’s offense. In the last three games, Smith-Schuster has notched 18-plus points in each game while totaling 25 targets from Mahomes. With Smith-Schuster seemingly being the No. 2 option alongside Travis Kelce, he looks like a nice option in Week 10 against the Jaguars, who have allowed the third-most receiving touchdowns to WRs.

Related: Week 10 Fantasy Football Must Starts + Players To Give Up On

Zay Jones @ KC ($4,400)

More value will likely open up by Sunday, but at the time this article is being written, Jones appears to be a solid salary-relief option. The veteran wideout continues to operate as the No. 2 receiver on the Jaguars, though, he’s seen his production decline in recent weeks. That being said, Jones has commanded five-plus targets in six of the eight games he’s appeared in this season. As previously mentioned, Jacksonville could be playing from behind versus Kansas City, so Jones could be more involved this week.

Tight Ends

Greg Dulcich @ TEN ($3,400)

Dulcich has quickly taken the starting job at tight end for the Broncos in recent weeks. The rookie tight end has now made three straight starts and he’s recorded 11-plus points on DraftKings in each of them. It’s clear that Russell Wilson trusts Dulcich in the passing game as he’s totaled 17 targets in his first three starts. The matchup is favorable for Dulcich this week as he’ll take on a Titans squad that is allowing the 10th-most points per game and the 5th-most yards per reception to TEs.

Foster Moreau vs. IND ($3,200)

Depending on the status of Darren Waller, Moreau is setting up to be a viable cash-game option on DraftKings again. Moreau has earned five-plus targets in three consecutive games despite being limited to a combined 20.3 points in those three games. We need to save salary at tight end and defense in cash games, so using $3,200 on Moreau to get somewhere around six-to-ten points on DraftKings shouldn’t cost us. If Waller is active this week, you can go down to Juwan Johnson at $3,000 or Tanner Hudson at $2,600.


Pittsburgh Steelers vs. NO ($2,800)

There’s a chance that T.J. Watt returns for the Steelers this week, which would be bad news for Andy Dalton and the Saints on the road. Even if Watt doesn’t play, Dalton is prone to making mistakes and Pittsburgh still has enough playmakers on defense to make them a solid play at $2,800.

Minnesota Vikings @ BUF ($2,200)

With all of the uncertainty surrounding Josh Allen for the Bills, I have a feeling I’ll be inserting the Vikings’ defense in my cash games. Minnesota’s defense is only $2,200 on DraftKings and they’ve produced 10-plus points in two of its last three games. If Case Keenum starts for the Bills on Sunday, the Vikings’ defense is an absolute lock for cash games.

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