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NFL DFS Picks for Week 6 DraftKings Main Slate

Tyler Lockett WR1 SZN continues vs the Cardinals. Here are the top picks at each position for DraftKings Week 6 NFL DFS main slate.

Whenever you have something good going, there’s no reason to switch things up. If you’ve been following the picks in these articles, you should be having plenty of success in cash games in NFL DFS over on DraftKings to begin the 2022 campaign.

My cash-game lineup recorded 180.04 points in Week 5 and it was led by Tom Brady, Leonard Fournette, Rhamondre Stevenson, Tyler Lockett, and the defense of the Dallas Cowboys. I was able to get 134.54 points out of those five spots in my cash games, so I didn’t need much more from the other players to be in the green.

Value typically opens up closer to gameday, so it’s crucial to keep tabs on injury news throughout the week as the ideal cash-game plays could change constantly. You can reach out to me over on Twitter @skyler_carlin if you need any help with cash or GPP lineup decisions.

With plenty of exciting games on tap in Week 6, here are my favorite cash-game plays for the main slate on DraftKings.


Josh Allen @ KC ($8,200)

Allen has been included in this article in recent weeks, and if DraftKings refuses to raise his salary, he’ll continue being a viable option in cash games. The former first-round pick has notched 30+ points in four of the first five weeks and he has a playoff rematch versus the Chiefs in Week 6, which has the highest projected total at 54 points.

The Bills don’t have much of a running game and Allen is always a threat to score a rushing touchdown, giving him a high floor and a high ceiling every single week.

Tom Brady @ PIT ($6,300)

The offense of the Buccaneers finally showed signs of life last week against the Falcons as Brady threw for 351 yards and a touchdown. The good news for the future Hall of Fame quarterback is that he gets to go up against the Steelers this week, who have given up the third-most passing yards in the NFL.

Also, with Tampa Bay’s offensive line struggling at times to begin the season, they should excel versus a Pittsburgh defense that has the fourth-lowest pressure rate.

Geno Smith vs. ARI ($5,700)

Geno for MVP? Smith won the starting job for the Seahawks this season following the trade of Russell Wilson and he’s managed to make the most of his opportunity thus far. The West Virginia product has averaged 27.2 points in the last three weeks and he’s still under $6,000 on the green site.

The veteran quarterback is the ideal spend-down option at quarterback in cash games, especially with the Seahawks hosting the Cardinals in the game with the second-highest projected total at 51 points.

Running Backs

Saquon Barkley vs. BAL ($7,700)

Volume is king in cash games and we know that Barkley is the engine that makes the offense of the Giants run. He’s commanding a massive 85.1% opportunity share percentage, which is the second-highest mark among RBs. It’s awesome to watch a healthy version of Barkley again this season as he’s eclipsed 100-plus scrimmage yards in four of the first five weeks.

Even with a perceived tough matchup against the Ravens in Week 6, the superstar running back is in line for 15-20 attempts and 5+ targets every week, making him an ideal option in cash games.

Rhamondre Stevenson @ CLE ($6,000)

We got a glimpse of what Stevenson is capable of as a starter in the NFL last week as he scored 22.5 points at $5,500. After getting a favorable matchup versus the Lions in Week 5, the second-year back will get an opportunity to face the dismal run defense of the Browns in Week 6.

Related: Week 6 Must Starts + Things We’d Rather Do Than Watch TNF

Cleveland is allowing 5.9 yards per attempt (second-worst in the NFL) and 8 total touchdowns (tied for most in the NFL) to RBs. Damien Harris was upgraded from doubtful to questionable in Week 6, so keep tabs on his status before confidently using Stevenson in cash games if he’s ruled out.

Eno Benjamin @ SEA ($4,600)

Benjamin could be in store for an expanded workload in Week 6 if James Conner is inactive for the Cardinals on Sunday. Darrel Williams has already been ruled out, so Benjamin has a chance to be a smash play at his current salary on DraftKings.

The second-year running back posted 14.3 points in relief of an injured Conner in Week 5 and he has a meeting with the Seahawks in Week 6, who have the worst run defense NEFF rating this season. Jeff Wilson Jr. ($6,200) and Kenneth Walker ($5,400) are other value options at running back in Week 6.

Wide Receivers

Stefon Diggs @ KC ($8,400)

Everyone will want to have exposure to the showdown between the Bills and the Chiefs in cash games this week. Regardless of whether or not you use Allen at quarterback, Diggs is poised to be a fantastic choice on DraftKings.

After combining for only 24.6 points in Week 3 and Week 4, the Pro Bowl wideout registered 27.2 points in Week 6. Diggs has gotten nine-plus targets in four of the first five weeks and he should be heavily involved in a potential shootout versus the Chiefs on Sunday.

Tyler Lockett vs. ARI ($5,600)

The wide receivers on the Seahawks have benefited from the hot start to the season from Smith. D.K. Metcalf and Lockett are both viable in Week 6, however, Lockett is $1,200 cheaper on DraftKings despite having only three fewer targets than his running mate.

I’m not a big advocate for using previous performances against a certain team in NFL DFS, but the experienced wideout has combined for 33 receptions, 480 receiving yards, and 6 receiving touchdowns in his last four meetings with the Cardinals.

Rondale Moore @ SEA ($4,200)

On the other side of the field as Lockett, the Cardinals have gotten Moore back in recent weeks and he’s actually seeing a positive aDOT, which wasn’t the case last season. The second-year wide receiver caught 7 passes for 68 yards last week and he should continue seeing a solid target share until DeAndre Hopkins returns next week.

Moore is going to run the majority of his routes out of the slot and Seattle’s defense is giving up most of its points to WRs to slot receivers.

Tight Ends

Zach Ertz @ SEA ($4,900)

Another player that’s benefited from Hopkins being sidelined to begin the season for the Cardinals is Ertz. The ceiling certainly isn’t high for the veteran tight end, but he’s managed to record at least 10.5 points in each game this season.

Ertz owns an 18.7% target share (fourth-highest among TEs) entering Week 6 and the Seahawks have given up the most fantasy points to TEs this season.

Tyler Higbee vs. CAR ($4,600)

As I’ve mentioned in previous weeks, Higbee is going to see an increase in usage until Van Jefferson returns for the Rams. With Jefferson sidelined, Higbee has seen a massive 24.7% target share in the first five weeks, which is only lower than Mark Andrews at the tight end position.

It also helps that the offensive line of the Rams has been atrocious this season, so Higbee is getting plenty of quick passes.

David Njoku vs. NE ($4,000)

Njoku is another name that’s been popular in my cash-game articles this season with the Browns finally using him consistently in the passing game. The athletic tight end has a solid 18% target share (seventh-highest among TEs) as he’s gotten five-plus targets in four consecutive games.

The Patriots have been a formidable defense to begin the season, but they’ve surrendered the second-most receiving touchdowns (5) to TEs this season.


Carolina Panthers @ LAR ($2,400)

There are undoubtedly other defenses like the 49ers ($3,700), the Buccaneers ($3,900), or the Rams ($4,100) that are viable in Week 6. However, it’s hard not to plug and play the Panthers at only $2,400 on DraftKings in a matchup with the Rams in Week 6. The Rams lack a running game, they’ve allowed 21 sacks, and Matthew Stafford has turned the ball over 10 times.

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